Brain / Cognitive function

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways.
Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY.
Korean J Physiol Pharmacol. 2015, 19(3), 219-228.

Multifunctional Activity of Polyphenolic Compounds Associated with a Potential for Alzheimer's Disease Therapy from Ecklonia cava.
Choi BW, Lee HS, Shin HC, Lee BH.
Phytother Res . 2015. 29(4), 549-553.

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors.
Kwak JH, Yang Z, Yoon B, He Y, Uhm S, Shin HC, Lee BH, Yoo YC, Lee KB, Han SY, Kim JS.
Biomaterials 2015, 61, 52-60.

Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis. Arch Pharm Res.
Choi JS, Haulader S, Karki S, Jung HJ, Kim HR, Jung HA.
Arch Pharm Res. 2015, 38(8), 1477-1487.

Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice.
Yoon M, Kim JS, Jo J, Han D, Cho S.
Fish Aquat Sci. 2014, 17(1), 19-25.

The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats.
Kim JG, Lim DW, Cho S, Han D, Kim YT.
Molecules. 2014, 19(6), 7669-7678.

Effect of Ecklonia cava Extracts Supplementation on cognitive ability in mice.
Oh JK, Song KJ, Ji MY, Yoon JH.
Kor J Herbology 2014, 29(6), 103-109.

Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.
Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL.
Psychopharmacology (Berl). 2014, 231(14), 2825-2837.

Acetylcholinesterase inhibitory activity of phlorotannins isolated form the brown alga, Ecklonia maxima (Osbeck) Papenfuss.
Kannan, R.R.R., Aderogba, M.A., Ndhlala, A.R., Stirk, W.A., Van Staden, J.
Food Research Internatioanl. 2013, 54, 1250-1254.

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH(2)-Terminal Kinases, and Akt in Microglial Cells.
Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR.
Inflammation. 2013, 36(2), 259-271.

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity.
Kang IJ, Jang BG, In S, Choi B, Kim M, Kim MJ.
Neurotoxicology. 2013, 34, 16-24.

Neuroprotective Mechanisms of Antioxidant Dieckol against Microglia-mediated Neurotoxicity and Mitochondrial-dependent Neuronal Cell Death.
Cui YJ.
PhD Thesis (Aug, 2012), Department of Physiology, Graduate School, Jeju Natioanl University.

Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells.
Ahn BR, Moon HE, Kim HR, Jung HA, Choi JS.
Arch Pharm Res. 2012, 35(11), 1989-1998.

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H(2)O(2)-induced oxidative stress in murine hippocampal HT22 cells.
Kang SM, Cha SH, Ko JY, Kang MC, Kim D, Heo SJ, Kim JS, Heu MS, Kim YT, Jung WK, Jeon YJ.
Environ Toxicol Pharmacol. 2012, 34(1), 96-105.

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction from Ecklonia cava Edible Brown Seaweed.
Cho S, Han D, Kim SB, Yoon M, Yang H, Jin YH, Jo J, Yong H, Lee SH, Jeon YJ, Shimizu M.
Biosci Biotechnol Biochem. 2012, 76(1), 163-168.

Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain.
Kim JH, Lee NS, Jeong YG, Lee JH, Kim EJ, Han SY.
Anat Cell Biol. 2012, 45(2), 103-113.

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death.
Kang IJ, Jeon YE, Yin XF, Nam JS, You SG, Hong MS, Jang BG, Kim MJ.
Food Chem Toxicol. 2011, 49(9), 2252-2259.

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity.
Jung HA, Oh SH, Choi JS.
Bioorg Med Chem Lett . 2010, 20(11), 3211-3215.

Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells.
Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW.
J Agric Food Chem. 2009, 57(10), 4439-4446.

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways.
Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi I, Park AG, Seo SK, Lee SW, Choi IW.
Food Chem Toxicol. 2009, 47(2), 410-407.

Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia Stolonifera.
Yoon NY, Chung HY, Kim HR, Choi JA,
Fisheries Science. 2008, 74, 200-207.

Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase.
Myung CS, Shin HC, Bao HY, Yeo SJ, Lee BH, Kang JS.
Arch Pharm Res. 2005, 28(6), 691-698.

Improvement of Learning Behavior of Mice by an Antiacetylcholinesterase and Neuroprotective Agent NX42, a Laminariales-Alga Extract.
Lee BH, Stein SM.
Korean J Food Sci Technol. 2004, 36(6), 974-978.

Summary Note for the Effect of Ecklonia cava Extract in Cognitive Function as Measured by MMSE in Eldery Subjects.
Lee BH, Shin HC.
Research Note (2003).

Down regulation of beta-APP by LSL4692 (Ecklonia cava polyphenol).
Lee BH.
Research Note (2002)

Neuroprotection from beta-Amyloid Toxicity by Ecklonia cava Extract.
Lee SH, Shin HC.
Research Note (2001)