Cancer / Chemoprevention

Evaluation of Effective MMP Inhibitors from Eight Different Brown Algae in Human Fibrosarcoma HT1080 Cells.
Bae MJ, Karadeniz F, Ahn BN, Kong CS.
Prev Nutr Food Sci. 2015, 20(3), 153-161.

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration.
Kim EK, Tang Y, Kim YS, Hwang JW, Choi EJ, Lee JH, Lee SH, Jeon YJ, Park PJ.
Mar Drugs. 2015, 13(4), 1785-1797.

A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis.
Ahn G, Lee W, Kim KN, Lee JH, Heo SJ, Kang N, Lee SH, Ahn CB, Jeon YJ.
EXCLI J. 2015, 14, 294-306.

Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.
Li YX, Li Y, Je JY, Kim SK.
Environ Toxicol Pharmacol. 2015, 39(1), 259-70.

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth.
Ahn JH, Yang YI, Lee KT, Choi JH.
J Cancer Res Clin Oncol. 2015, 141(2), 255-268.

Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition.
Kim RK, Suh Y, Yoo KC, Cui YH, Hwang E, Kim HJ, Kang JS, Kim MJ, Lee YY, Lee SJ.
Cancer Sci. 2015, 106(1), 94-101.

Brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity.
Yang YI, Ahn JH, Choi YS, Choi JH.
Gynecol Oncol. 2014, 136(2), 355-364.

Cardioprotective effects of Eckonia cava polyphenol against doxorubicin-induced cardiotoxicity in an amimal rat model with the evidence of electron microscopic finding.
Ahn, HS, Jeon, HK, Kim GH, Chung, WB, Cho, JS, Kim MJ, Cho, EJ, Jung, HO, Youn, HJ.
J Am Coll Cardiol. 2014, 63(12_S), A873.

Structure, enzymatic transformation and anticancer activity of branched high molecular weight laminaran from brown alga Eisenia bicyclis.
Menshova RV, Ermakova SP, Anastyuk SD, Isakov VV, Dubrovskaya YV, Kusaykin MI, Um BH, Zvyagintseva TN.
Carbohydr Polym. 2014, 99, 101-109.

Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity.
Ermakova S, Men'Shova R, Vishchuk O, Kim SM, Um BH, Isakov V, Zvyaginteseva T.
Algagl Research. 2013, 2(1), 51-58.

Cardioprotective effects of seapolynol (polyphenol purified from ecklonia cava) against adriamycin-induced cardiomyopathy in an animal rat model.
Jeon HK, Lee DH, Youn HJ, Shin HC.
European J Heart Failure. 2013, 12(1), S101.

Dieckol, isolated from Ecklonia stolonifera, induces apoptosis in human hepatocellular carcinoma Hep3B cells.
Yoon JS, Kasin Yadunandam A, Kim SJ, Woo HC, Kim HR, Kim GD.
J Nat Med. 2013, 67(3), 519-527.

Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling.
Park SJ, Jeon YJ.
Mol Cells. 2012, 33(2), 141-149.

Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells.
Park SJ, Kim YT, Jeon YJ.
Mol Cells. 2012, 33(4), 363-399.

Phloroglucinol Inhibits the Bioactivities of Endothelial Progenitor Cells and Suppresses Tumor Angiogenesis in LLC-Tumor-Bearing Mice.
Kwon YH, Jung SY, Kim JW, Lee SH, Lee JH, Lee BY, Kwon SM.
PLoS One. 2012, 7(3), e33618.

Cardioprotective effects of seapolynol (polyphenol purified from ecklonia cava) against adriamycin-induced cardiomyopathy in an animal rat model.
Jeon HK, Lee DH, Shin HC, Youn HJ, Kim KT.
European Heart J. 2012, 33(Supl 1), 328.

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK.
Evid Based Complement Alternat Med. 2011, 2011, 140462.

Dieckol Inhibits 12-O-tetradecanoylphorbol-13-acetate-induced SK-Hep1 Human Hepatoma Cell Motility through Suppression of Matrix Metalloproteinase-9 Activity.
Oh SM, Park CG, Kang JH, Kim EJ, Chee HY, Lee BH, Lee KB.
J Korean Soc Appl Biol Chem. 2011, 54(3), 376-381.

Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells.
Hyun KH, Yoon CH, Kim RK, Lim EJ, An S, Park MJ, Hyun JW, Suh Y, Kim MJ, Lee SJ.
Toxicol Appl Pharmacol. 2011, 254(1), 32-40.

Cytotoxic Activities of Phlorethol and Fucophlorethol Derivatives Isolated From Laminariaceae Ecklonia cava.
Li Y, Qian ZJ, Kim MM, Kim SK.
J Food Biochem. 2011, 35(2), 357-369.

Anticancer drugs from marine flora: an overview.
Sithranga Boopathy N, Kathiresan K.
J Oncol. 2010, 2010, 214186.

Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava.
Zhang C, Li Y, Shi X, Kim SK.
BMB Rep. 2010, 43(1), 62-68.

Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo.
Kang KA, Zhang R, Chae S, Lee SJ, Kim J, Kim J, Jeong J, Lee J, Shin T, Lee NH, Hyun JW.
Chem Biol Interact. 2010, 185(3), 215-226.

Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells.
Kong CS, Kim JA, Yoon NY, Kim SK.
Food Chem Toxicol. 2009, 47(7), 1653-1658.

Matrix Metalloproteinase Inhibitors (MMPIs) from Marine Natural Products: the Current Situation and Future Prospects.
Zhang C, Kim SK.
Mar Drugs. 2009, 7(2), 71-84.

MMT Inhibitory Action of Seanol.
Saeki Y, NishiuraH, Tanaka K.
Fragrance J. 2009, 37, 94-96.

Eckol protects V79-4 lung fibroblast cells against γ-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH2-terminal kinase pathway.
Zhang R, Kang KA, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Jeong IY, Shin T, Park JW, Lee NH, Hyun JW.
Eur J Pharm. 2008, 591(1-3), 114-123.

Modulation of apoptosis of eckol against ionizing radiation in mice.
Park E, Lee NH, Joo HG, Jee Y.
Biochem Biophys Res Commun. 2008, 372(4), 792-797.

Radioprotective properties of eckol against ionizing radiation in mice.
Park E, Ahn GN, Lee NH, Kim JM, Yun JS, Hyun JW, Jeon YJ, Wie MB, Lee YJ, Park JW, Jee Y.
FEBS Lett. 2008, 582(6), 925-930.

Protective effect of phlorotannin components phlorogluciol and eckol on radiation- induced intestinal injury in mice.
Moon CM, Kim SH, Kim JC, Hyun JW, Lee NH, Park JW, Shin T.
Phytother Res. 2008, 22(2), 238-242.

Inhibitory efects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition.
Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Shin T, Park JW, Lee NH, Yoo BS, Hyun JW.
J Toxicol Environ Health. 2008, 7(15), 992-999.

Cytotoxic Activities of Green and Brown Seaweeds Collected from Jeju Island against Four Tumor Cell Lines.
Kim KN, Lee KW, Song CB, Jeon YJ.
J Food Sci Nutr. 2006, 11(1), 17-24

Elastase and hyaluronidase inhibition activities of phlorotannins isolated from Ecklonia cava.
Bu HJ, Ham YM, Kim JM, Lee SJ, Hyun JW, Lee NH.
Kor J Pharmacogn. 2006, 37(2), 92-96.

Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols.
Hwang H, Chen T, Nines RG, Shin HC, Stoner GD.
Int J Cancer . 2006, 119(12), 2742-2749.

The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts.
Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK.
Biol Pharm Bull. 2006, 29(8), 1735-1739.

Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity.
Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK.
Life Sci. 2006, 79(15), 1436-1443.

Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells.
Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Lee Y, Kim SY, Kim HS, Joo HG, Park JW, Ham YM, Lee NH, Hyun JW.
FEBS Lett, 2005, 579(28), 6295–6304.

Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage.
Kang KA, Lee KH, Chae S, Koh YS, Yoo BS, Kim JH, Ham YM, Baik JS, Lee NH, Hyun JW.
Free Radic Res. 2005, 39(8), 883–892.

Inhibitory activity of brown algal phlorotannins against hyaluronidase.
ShibataT, Fujimoto K, Nagayamak, Yamaguchi K, Nakamura T.
Int J Food Sci Tech. 2002, 37(6), 703-709.

Inhibitory effect of Ecklonia stolonifera on gene mutation on mouse lymphoma tk+/+ locus in L5178Y-3.7.2.C cell and bone marrow micronuclei formation in ddY mice. Environ.
Han, E.S., Kim, J.W., Eom, M.O., Kang, I.H., Kang, H.J., Choi, J.S., Ha, K.W. and Oh, H.Y.
Mutagen Carcinogen. 2000, 20, 104-111.

Preventive effect of Ecklonia stolonifera on the frequency of benzo(a)pyrene-induced chromosomal aberrations.
Lee JH, Oh HY, Choi JS,
J Food Sci Nutr. 1996, 1(1), 64-68.