Metabolism / Lipid / Sugar / Fat / Liver

Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation.
Choi HS, Jeon HJ, Lee OH, Lee BY.
Mol Nutr Food Res. 2015, 59(8), 1458-1471.

Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice.
Eo H, Jeon YJ, Lee M, Lim Y.
J Agric Food Chem. 2015, 63(1), 349-359.

Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner.
Yamashita H, Goto M, Matsui-Yuasa I, Kojima-Yuasa A.
Mar. Drugs 2015, 13, 3877-3891.

Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial.
Lee SH, Jeon YJ.
Food Funct. 2015, 6(3), 853-858.

Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.
Park EY, Choi H, Yoon JY, Lee IY, Seo Y, Moon HS, Hwang JH, Jun HS.
Mar Drugs. 2015, 13(11), 6866-6883.

Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice.
You HN, Lee HA, Park MH, Lee JH, Han JS.
Eur J Pharmacol. 2015, 752, 92-96.

Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Jeon HJ, Choi HS, Lee YJ, Hwang JH, Lee OH, Seo MJ, Kim KJ, Lee BY.
Molevcules 2015, 20(12), 21715-21731.

Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice.
Jeon HJ, Yoon KY, Koh EJ, Choi J, Kim KJ, Choi HS, Lee BY.
J Food Nutr Res. 2015, 3(10), 648-652.

6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells.
Kwon TH, Wu YX, Kim JS, Woo JH, Park KT, Kwon OJ, Seo HJ, Kim T, Park NH.
J Sci Food Agric. 2015, 95(3), 1830-1837.

6,6'-Bieckol Isolated from Ecklonia cava Protects Oxidative Stress Through Inhibiting Expression of ROS and Proinflammatory Enzymes in High-Glucose-Induced Human Umbilical Vein Endothelial Cells.
Park MH, Heo SJ, Park PJ, Moon SH, Sung SH, Jeon BT, Lee SH.
Appl Biochem Biotechnol. 2014, 174(2), 632-643.

Effect of Baechu Kimchi Added Ecklonia cava Extracts on High Glucose-induced Oxidative Stress in Human Umbilical Vein Endothelial Cells.
Lee HA, Song YO, Jang MS, Han JS.
Prev Nutr Food Sci. 2014, 19(3), 170-177.

Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ.
Jung HA, Jung HJ, Jeong HY, Kwon HJ, Ali MY, Choi JS.
Fitoterapia. 2014, 92, 260-269.

A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.
Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T.
Biosci Biotechnol Biochem. 2014, 78(5), 832-838.

Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo.
Kang MC, Kim KN, Chaminda Lakmal HH, Kim EA, Wijesinghe WA, Yang X, Heo SJ, Jeon YJ.
Environ Toxicol Pharmacol. 2014, 38(2), 607-615.

Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes.
Jung HA, Kim JI, Choung SY, Choi JS.
J Pharm Pharmacol. 2014, 66(8), 1180-1188.

Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes.
Jung HA, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS.
Arch Pharm Res. 2014, 37(6), 713-720.

Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model.
Kang MC, Kim KN, Kang SM, Yang X, Kim EA, Song CB, Nah JW, Jang MK, Lee JS, Jung WK, Jeon YJ.
Environ Toxicol Pharmacol. 2013, 36(3), 1217-1226.

Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model.
Kang MC, Wijesinghe WA, Lee SH, Kang SM, Ko SC, Yang X, Kang N, Jeon BT, Kim J, Lee DH, Jeon YJ.
Food Chem Toxicol. 2013, 53, 294-298.

Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes.
Ko SC, Lee M, Lee JH, Lee SH, Lim Y, Jeon YJ.
Environ Toxicol Pharmacol. 2013, 36(3), 1253-1260.

Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice.
Lee HA, Song YO, Jang MS, Han JS.
Prev Nutr Food Sci. 2013, 18(3), 163-168.

Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera.
Jung HA, Islam MN, Lee CM, Oh SH, Lee S, Jung JH, Choi JS.
Chem Biol Interact. 2013, 206(1), 55-62.

Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Kang YM, Eom SH, Kim YM.
Environ Toxicol Pharmacol. 2013, 35(3), 395-401.

Evaluation of Inhibitory Effect of Phlorotannins from Ecklonia cava on Triglyceride Accumulation in Adipocyte.
Kim H, Kong CS, Lee JI, Kim H, Baek S, Seo Y.
J Agric Food Chem. 2013, 61(36), 8541-8547.

Dieckol Isolated from Ecklonia cava Protects against High-Glucose Induced Damage to Rat Insulinoma Cells by Reducing Oxidative Stress and Apoptosis.
Lee SH, Park MH, Kang SM, Ko SC, Kang MC, Cho S, Park PJ, Jeon BT, Kim SK, Han JS, Jeon YJ.
Biosci Biotechnol Biochem. 2012, 76(8), 1445-1451.

Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus.
Lee SH, Min KH, Han JS, Lee DH, Park DB, Jung WK, Park PJ, Jeon BT, Kim SK, Jeon YJ.
Food Chem Toxicol. 2012, 50(3-4), 575-582.

Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice.
Kim MJ, Kim HK.
Asian Pac J Trop Med. 2012, 5(5), 374-379.

Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice.
Kim HK.
Evid Based Complement Alternat Med. 2012, 2012, 439294.

Bioactive Compounds Extracted from Ecklonia cava by Using Enzymatic Hydrolysis Protects High Glucose-Induced Damage in INS-1 Pancreatic β-Cells.
Lee SH, Park MH, Park SJ, Kim J, Kim YT, Oh MC, Jeong Y, Kim M, Han JS, Jeon YJ.
Appl Biochem Biotechnol. 2012, 167, 1973-1985.

Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-γ KO Mice.
Dwiranti F, Hiraoka M, Taguchi T, Konishi Y, Tominaga M, Tominaga A.
Int J Biomed Sci. 2012, 8(1), 64-75.

Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells.
Lee MS, Kim JI, Utsuki T, Park NG, Kim HR.
Fitoterapia. 2012, 83, 1060-1067.

α-Glucosidase- and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis.
Eom SH, Lee SH, Yoon NY, Jung WK, Jeon YJ, Kim SK, Lee MS, Kim YM.
J Sci Food Agric. 2012, 92(10), 2084-2090.

Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis.
Eom SH, Lee MS, Lee EW, Kim YM, Kim TH.
Phytother Res. 2012, 27, 148-151.

Antidiabetic effect of polyphenols from brown alga Ecklonia kurome in genetically diabetic KK-A(y) mice.
Xu HL, Kitajima C, Ito H, Miyazaki T, Baba M, Okuyama T, Okada Y.
Pharm Biol. 2012, 50(3), 393-400.

Isolation and Identification of Phlorotannins from Ecklonia stolonifera with Antioxidant and Hepatoprotective Properties in Tracrine-Treated HepG2 Cells.
Lee MS, Shin TS, Utsuki T, Choi JS, Byun DS, Kim HR.
J Agric Food Chem. 2012, 60(21), 5340-5349.

Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice.
Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ.
Food Chem Toxicol. 2012, ;50(6), 1986-1991.

Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice.
Park EY, Kim EH, Kim MH, Seo YW, Lee JI, Jun HS.
Evid Based Complement Alternat Med. 2012, 2012, 418912.

Anti-hyperlipidemic Effect of Polyphenol Extract (SeapolynolTM) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models.
Yeo AR, Lee J, Tae IH, Park SR, Cho YH, Lee BH, Shin HC, Kim SH, Yoo YC.
Prev Nutr Food Sci. 2012, 17, 1-7.

Effects of 12-week Oral Supplementation of Ecklonia cava Polyphenols on Anthropometric and Blood Lipid Parameters in Overweight Korean Individuals: A Double-blind Randomized Clinical Trial.
Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ.
Phytother Res. 2012, 26(3), 363-368.

Effects of Ecklonia cava Polyphenol in Individuals with Hypercholesterolemia: A Pilot Study.
Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK.
J Med Food. 2012, 15(11), 1038-1044.

Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.
Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A.
Biochim Biophys Acta. 2012, 1820, 978-988.

Inhibitory Effects of Ecklonia cava Extract on High Glucose-Induced Hepatic Stellate Cell Activation.
Yokogawa K, Matsui-Yuasa I, Tamura A, Terada M, Kojima-Yuasa A.
Mar Drugs. 2011, 9(12), 2793-2808.

Isolation of Phlorotannins from Eisenia bicyclis and Their Hepatoprotective Effect against Oxidative Stress Induced by tert-Butyl Hyperoxide.
Kim SM, Kang K, Jeon JS, Jho EH, Kim CY, Nho CW, Um BH.
Appl Biochem Biotechnol. 2011, 165(5-6), 1296-1307.

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae, Ecklonia stolonifera and Eisenia bicyclis.
Moon HE, Islam N, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, Choi JS.
Biosci Biotechnol Biochem. 2011, 75(8), 1472-1480.

Brown alga Ecklonia cava attanuates type 1 diabetes by activation AMPK and Ark signaling pathways.
Kang C, Jin YB, Lee H, Cha M, Sohn ET, Moon J, Park C, Chun S, Jung ES, Hong JS, Kim SB, Kim JS, Kim E.
Food Chem Toxicol. 2010, 48(2), 509-516.

Effect of Supplementation With Ecklonia cava Polyphenol on Endurance Performance of College Students.
Oh JK, Shin YO, Yoon JH, Kim SH, Shin HC, Hwang HJ.
Int J Sport Nutr Exerc Metab. 2010, 20(1), 72-79.

Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice.
Lee SH, Park MH, Heo SJ, Kang SM, Ko SC, Han JS, Jeon YJ.
Food Chem Toxicol. 2010, 48(10), 2633-2637.

Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes.
Kim SK, Kong CS.
Chem Biol Interact. 2010, 186(1), 24-29.

1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin inhibits adipocyte differentiation of 3T3-L1 fibroblasts.
Kong CS, Kim JA, Ahn BN, Vo TS, Yoon NY, Kim SK.
Mar Biotechnol (NY). 2010, 12(3), 299-307.

α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava.
Lee SH, Li Y, Karadeniz F, Kim MM, Kim SK.
J Sci Food Agric. 2009, 89(9), 1552-1558.

Anti-hyperlipidemic dffect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats.
Yoon NY, Kim HR, Chung HY, Choi JS.
Arch Pharm Res. 2008, 31(12), 1564-1571.

Antidiabetic antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetecally diabetic
KK-Ay mice.
Iwai K.
Plant Foods Hum Nutr. 2008, 63(4), 163-169.

Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine- induced cytotoxicity in Hep G2 cells.
Kim YC, An RB, Yoon NY, Nam TJ, Choi JS.
Arch Pharm Res. 2005, 28(12), 1376-1380.

A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications.
Okada Y, Ishimaru A, Suzuki R, Okuyama T.
J Nat Prod. 2004, 67(1), 103-105.

Inhibitory activity of brown algal phlorotannins against glycosidases from the viscera of the turban shell Turbo cornutus.
Shibata T, Yamaguchi K, Nagayama K, Kawaguchi S, Nakamura T,
Eur. J. Phycol. 2002, 37, 493-500.