Oxidative stress / Antioxidant / Free radical

The cytoprotective effects of ethanol extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK pathway.
Choi YH.
Gen Physiol Biophys. 2016, 35(1), 45-53.

Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation.
Choi HS, Jeon HJ, Lee OH, Lee BY.
Mol Nutr Food Res. 2015, 59(8), 1458-1471.

Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury.
Choi JS, Han YR, Byeon JS, Choung SY, Sohn HS, Jung HA.
J Pharm Pharmacol. 2015, 67(8), 1170-1178.

6,6'-Bieckol Isolated from Ecklonia cava Protects Oxidative Stress Through Inhibiting Expression of ROS and Proinflammatory Enzymes in High-Glucose-Induced Human Umbilical Vein Endothelial Cells.
Park MH, Heo SJ, Park PJ, Moon SH, Sung SH, Jeon BT, Lee SH.
Appl Biochem Biotechnol. 2014, 174(2), 632-643.

Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.
Yayeh T, Im EJ, Kwon TH, Roh SS, Kim S, Hong SB, Cho JY, Park NH, Rhee MH.
Int Immunopharmacol 2014, 22(1), 51-58.

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells.
Jun YJ, Lee M, Shin T, Yoon N, Kim JH, Kim HR.
Molecules. 2014, 19(10), 15638-15652.

Cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: Involvement of the FoxO3a/AMPK pathway.
Kim AD, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW.
J Cell Biochem. 2014, 115(8), 1403-1411.

Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage.
Kim KC, Piao MJ, Zheng J, Yao CW, Cha JW, Kumara MH, Han X, Kang HK, Lee NH, Hyun JW.
Biomol Ther (Seoul). 2014, 22(4), 301-307.

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1.
Kim KC, Lee IK, Kang KA, Piao MJ, Ryu MJ, Kim JM, Lee NH, Hyun JW.
Mar Drugs. 2014, 12(11), 5357-5371.

Cytoprotective effect of dieckol on human endothelial progenitor cells (hEPCs) from oxidative stress-induced apoptosis.
Lee SH, Kim JY, Yoo SY, Kwon SM.
Free Radic Res. 2013, 47(6-7), 526-534.

Antioxidant activity of various solvent fractions from edible brown alga, Eisenia bicyclis and its active compounds.
Kwon TH, Kim TW, Kim CG, Park NH.
J Food Sci. 2013, 78(5), C679-C684.

Potential antiradical and alpha-glucosidase inhibitors from Ecklonia maxima (Osbeck) Papenfuss.
Rengasamy KR, Aderogba MA, Amoo SO, Stirk WA, Van Staden J.
Food Chem. 2013, 141(2), 1412-1415.

Isolation and structural determination of two novel phlorotannins from the brown alga Ecklonia kurome Okamura, and their radical scavenging activities.
Yotsu-Yamashita M, Kondo S, Segawa S, Lin YC, Toyohara H, Ito H, Konoki K, Cho Y, Uchida T.
Mar Drugs. 2013, 11(1), 165-183.

Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo.
Kang MC, Cha SH, Wijesinghe WA, Kang SM, Lee SH, Kim EA, Song CB, Jeon YJ.
Food Chem. 2013, 138(2-3), 950-955.

Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells.
Park SJ, Kim YT, Jeon YJ.
Mol Cells. 2012, 33(4), 363-399.

Neuroprotective Mechanisms of Antioxidant Dieckol against Microglia-mediated Neurotoxicity and Mitochondrial-dependent Neuronal Cell Death.
Cui YJ.
PhD Thesis (Aug, 2012), Department of Physiology, Graduate School, Jeju Natioanl University.

Edible seaweed, Eisenia bicyclis, protects retinal ganglion cells death caused by oxidative stress.
Kim KA, Kim SM, Kang SW, Jeon SI, Um BH, Jung SH.
Mar Biotechnol (NY). 2012, 14(4), 383-395.

Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress.
Piao MJ, Lee NH, Chae S, Hyun JW.
Biol Pharm Bull. 2012, 35(6), 873-880.

Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes.
Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW.
Environ Toxicol Pharmacol. 2012, 34(3), 926-934.

Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells.
Lee MS, Kim JI, Utsuki T, Park NG, Kim HR.
Fitoterapia. 2012, 83, 1060-1067.

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H(2)O(2)-induced oxidative stress in murine hippocampal HT22 cells.
Kang SM, Cha SH, Ko JY, Kang MC, Kim D, Heo SJ, Kim JS, Heu MS, Kim YT, Jung WK, Jeon YJ.
Environ Toxicol Pharmacol. 2012, 34(1), 96-105.

Isolation and Identification of Phlorotannins from Ecklonia stolonifera with Antioxidant and Hepatoprotective Properties in Tracrine-Treated HepG2 Cells.
Lee MS, Shin TS, Utsuki T, Choi JS, Byun DS, Kim HR.
J Agric Food Chem. 2012, 60(21), 5340-5349.

Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.
Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A.
Biochim Biophys Acta. 2012, 1820, 978-988.

Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6'-bieckol isolated from brown algae, Ecklonia cava.
Kang SM, Lee SH, Heo SJ, Kim KN, Jeon YJ.
Nutr Res Pract. 2011, 5(6), 495-502.

Comparative antioxidant activity of edible Japanese brown seaweeds.
Airanthi MK, Hosokawa M, Miyashita K.
J Food Sci. 2011. 76(1), C104-C111.

Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells.
Lee SH, Han JS, Heo SJ, Hwang JY, Jeon YJ.
Toxicol In Vitro. 2010, 24(2), 375-381.

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt.
Kim KC, Kang KA, Zhang R, Piao MJ, Kim GY, Kang MY, Lee SJ, Lee NH, Surh YJ, Hyun JW.
Int J Biochem Cell Biol. 2010, 42(2), 297-305.

Cytoprotective effects of triphlorethol-A against formaldehyde-induced oxidative damage and apoptosis: role of mitochondria-mediated caspase-dependent pathway.
Zhang R, Lee IK, Kang KA, Piao MJ, Kim KC, Kim BJ, Lee NH, Choi JY, Choi J, Hyun JW.
J Toxicol Environ Health A. 2010, 73(21-22), 1477-1489.

Protective effects of enzymatic digest from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells.
Lee SH, Heo SJ, Hwang JY, Han JS, Jeon YJ.
J Sci Food Agric. 2010, 90(2), 349-356.

Effect of phloroglucinol on oxidative stress and inflammation.
Kim MM, Kim SK.
Food Chem Toxicol. 2010, 48(10), 2925-2933.

Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo.
Kang KA, Zhang R, Chae S, Lee SJ, Kim J, Kim J, Jeong J, Lee J, Shin T, Lee NH, Hyun JW.
Chem Biol Interact. 2010, 185(3), 215-226.

Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties.
Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Kim HR.
J Agric Food Chem. 2009, 57(9), 3483-3489.

Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava.
Li Y, Qian ZJ, Ryu B, Lee SH, Kim MM, Kim SK.
Bioorg Med Chem. 2009, 17(5), 1963-1973.

Eckol protects V79-4 lung fibroblast cells against γ-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH2-terminal kinase pathway.
Zhang R, Kang KA, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Jeong IY, Shin T, Park JW, Lee NH, Hyun JW.
Eur J Pharm. 2008, 591(1-3), 114-123.

Inhibitory efects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition.
Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Shin T, Park JW, Lee NH, Yoo BS, Hyun JW.
J Toxicol Environ Health. 2008, 7(15), 992-999.

Identification of chemical structure and free radical scavenging activity of diphlorethohydroxycarmalol isolated from a brown alga, Ishige okamurae.
Heo SJ, Kim JP, Jung WK, Lee NH, Kang HS, Jun EM, Park SH, Kang SM, Lee YJ, Park PJ, Jeon YJ.
J Microbiol Biotechnol. 2008, 18(4), 676-681.

Antioxidant activities of phlorotannins isolated from Japanese Laminariaceae.
Shibata T, Ishimaru K, Kawaguchi S, Yoshikawa H, Hama Y.
J Appl Phycol. 2008, 20, 705-711.

Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor.
Kang KA, Lee KH, Park JW, Lee NH, Na HK, Surh YJ, You HJ, Chung MH, Hyun JW.
FEBS Lett . 2007, 581(10), 2000–2008.

Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage.
Ahn GN, Kim KN, Cha SH, Song CB, Lee J, Heo MS, Yeo IK, Lee NH, Jee YH, Kim JS.
Eur Food Res Technol. 2007, 226(1), 71–79.

An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava.
Shin HC, Hwang HJ, Kang KJ, Lee BH.
Arch Pharm Res. 2006, 29(2), 165-171.

Antioxidant potential of Ecklonia cava on reactive oxygen species scavenging, metal chelating, reducing power and lipid peroxidation inhibition.
Senevirathne M, Kim SH, Siriwardhana N, Ha JH, Lee KW Jeon YJ.
Food Sci Tech Int. 2006, 12(1), 27–38

Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava.
Athukorala Y, Kim KN, Jeon YJ.
Food Chem Toxicol. 2006, 44(7), 1065–1074.

Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation.
Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Ham YM, Baik JS, Lee NH, Hyun JW.
J Cell Biochem. 2006, 97(3), 609–620.

Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells.
Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Lee Y, Kim SY, Kim HS, Joo HG, Park JW, Ham YM, Lee NH, Hyun JW.
FEBS Lett, 2005, 579(28), 6295–6304.

Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage.
Kang KA, Lee KH, Chae S, Koh YS, Yoo BS, Kim JH, Ham YM, Baik JS, Lee NH, Hyun JW.
Free Radic Res. 2005, 39(8), 883–892.

Suppression of iNOS expression by phlorotannins in chronic exposure of skin to UVB radiation.
Hwang H, Chen T, Stoner GD, Lee KB, Yoo YC, Shin HC.
Lab Anim Res. 2005, 21(4), 385-389.

Antioxidant activity of enzymatic extracts from brown seaweeds.
Heo SJ, Park EJ, Lee KW, Jeon YJ.
Bioresour Techno. 2005, 96(14), 1613-1623.

Antioxidant activity of enzymatic extracts from a brown seaweed ecklonia cava by electron spin resonance spectrometry and comet assay.
Heo SJ, Park PJ, Park EJ, Kim SK, Jeon YJ.
Eur Food Res Technol. 2005, 221(1), 41-47.

Antioxidative effect of proteolytic hydrolysates from ecklonia cava on radical scavenging using ESR and H2O2 induced DNA damage.
Heo SJ, Park PJ, Park EJ, Cho SK, Kim SK, Jeon YJ.
Food Sci Biotechnol. 2005, 14(5), 614-620.

Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation.
Kang HS, Chung HY, Kim JY, Son BW, Jung HA, Choi JS.
Arch Pharm Res. 2004, 27(2), 194-198.

Improvement of Learning Behavior of Mice by an Antiacetylcholinesterase and Neuroprotective Agent NX42, a Laminariales-Alga Extract.
Lee BH, Stein SM.
Korean J Food Sci Technol. 2004, 36(6), 974-978.

The antioxidant activity and tyrosinase inhibitory activity of phlorotannins in Ecklonia cava.
Kim, J.A., Lee, J.M., Shin, D.B. and Lee, N.H.
Food Sci Biotech. 2004, 13(4), 476–480.

Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors.
Kang K, Park YJ, Hwang HJ, Kim SH, Lee JG, Shin HC.
Arch Pharm Res. 2003, 26(4), 286-293.

Antioxidant activity of Hizikia fusiformis on reactive oxygen species scavenging and lipid peroxidation inhibition.
Siriwardhana, N., Lee, K.W., Kim, S.H., Ha, W.J., Jeon, Y.J.
Food Science and Technology International. 2003, 9(5), 339–346.

Antioxidant effect of enzymatic hydrolyzate from a Kelp, Ecklonia cava.
Heo SJ, Jeon YJ, Lee JH, Kim HT, Lee KW.
Algae. 2003, 18(4), 341–347.

Antioxidant activity of enzymatic extracts from brown seaweeds.
Heo SJ, Lee KW, Song CB, Jeon YJ.
Algae. 2003, 18(1), 71-81.

Peroxynitrite scavenging activity of phloroglucinol from Ecklonia stolonifera.
Chung HY, Choi HR, Park HJ, Choi JS, Choi WC.
J Kor Assoc Cancer Prevent. 2000, 5(1), 1-6.

The Screening of Nitrite scavenging effect of marine algae and Active principles of Ecklonia Stolonifera.
Choi JS, Lee JH, Jung JH,
J Korean Fish Soc. 1997, 30(6), 909-915.

Antioxidant activity of phlorotannins isolated from the brown alga Eisenia bicyclis.
Nakamura T, Nagayama K, Uchida K, Tanaka R.
Fisheries Science (Japan). 1996, 62(6), 923-926.