Publication Year: 2015 - 2016


Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols.
Shin H, Cho AR, Kim DY, Munkhbayer A, Choi SJ, Jang S, Kim SH, Shin HC, Kwon O.
Ann Dermatol. 2016, 28(1), 15-21.

Protective Effect of Brown Alga Phlorotannins against Hyper-inflammatory Responses in Lipopolysaccharide-Induced Sepsis Models.
Yang YI, Woo JH, Seo YJ, Lee KT, Lim Y, Choi JH.
J Agric Food Chem. 2016, 64(3), 570-578.

The cytoprotective effects of ethanol extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK pathway.
Choi YH.
Gen Physiol Biophys. 2016, 35(1), 45-53.


Evaluation of Effective MMP Inhibitors from Eight Different Brown Algae in Human Fibrosarcoma HT1080 Cells.
Bae MJ, Karadeniz F, Ahn BN, Kong CS.
Prev Nutr Food Sci. 2015, 20(3), 153-161.

Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction.
Ahn G, Amagai Y, Matsuda A, Kang SM, Lee W, Jung K, Oida K, Jang H, Ishizaka S, Matsuda K, Jeon YJ, Jee Y, Matsuda H, Tanaka A.
Exp Dermatol. 2015, 24, 968-970.

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration.
Kim EK, Tang Y, Kim YS, Hwang JW, Choi EJ, Lee JH, Lee SH, Jeon YJ, Park PJ.
Mar Drugs. 2015, 13(4), 1785-1797.

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways.
Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY.
Korean J Physiol Pharmacol. 2015, 19(3), 219-228.

Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation.
Choi HS, Jeon HJ, Lee OH, Lee BY.
Mol Nutr Food Res. 2015, 59(8), 1458-1471.

The anti-aging properties of a human placental hydrolysate combined with dieckol isolated from Ecklonia cava.
Jang SK, Lee do I, Kim ST, Kim GH, Park da W, Park JY, Han D, Choi JK, Lee YB, Han NS, Kim YB, Han J, Joo SS.
BMC Complement Altern Med. 2015, 15, 345.

Multifunctional Activity of Polyphenolic Compounds Associated with a Potential for Alzheimer's Disease Therapy from Ecklonia cava.
Choi BW, Lee HS, Shin HC, Lee BH.
Phytother Res . 2015. 29(4), 549-553.

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors.
Kwak JH, Yang Z, Yoon B, He Y, Uhm S, Shin HC, Lee BH, Yoo YC, Lee KB, Han SY, Kim JS.
Biomaterials 2015, 61, 52-60.

Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice.
Eo H, Jeon YJ, Lee M, Lim Y.
J Agric Food Chem. 2015, 63(1), 349-359.

Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner.
Yamashita H, Goto M, Matsui-Yuasa I, Kojima-Yuasa A.
Mar. Drugs 2015, 13, 3877-3891.

Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial.
Lee SH, Jeon YJ.
Food Funct. 2015, 6(3), 853-858.

Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.
Park EY, Choi H, Yoon JY, Lee IY, Seo Y, Moon HS, Hwang JH, Jun HS.
Mar Drugs. 2015, 13(11), 6866-6883.

Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury.
Choi JS, Han YR, Byeon JS, Choung SY, Sohn HS, Jung HA.
J Pharm Pharmacol. 2015, 67(8), 1170-1178.

Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway.
Ryu B, Ahn BN, Kang KH, Kim YS, Li YX, Kong CS, Kim SK, Kim DG.
J Photochem Photobiol B. 2015, 153, 352-357.

Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice.
You HN, Lee HA, Park MH, Lee JH, Han JS.
Eur J Pharmacol. 2015, 752, 92-96.

Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Jeon HJ, Choi HS, Lee YJ, Hwang JH, Lee OH, Seo MJ, Kim KJ, Lee BY.
Molevcules 2015, 20(12), 21715-21731.

Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice.
Jeon HJ, Yoon KY, Koh EJ, Choi J, Kim KJ, Choi HS, Lee BY.
J Food Nutr Res. 2015, 3(10), 648-652.

A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis.
Ahn G, Lee W, Kim KN, Lee JH, Heo SJ, Kang N, Lee SH, Ahn CB, Jeon YJ.
EXCLI J. 2015, 14, 294-306.

6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells.
Kwon TH, Wu YX, Kim JS, Woo JH, Park KT, Kwon OJ, Seo HJ, Kim T, Park NH.
J Sci Food Agric. 2015, 95(3), 1830-1837.

Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.
Li YX, Li Y, Je JY, Kim SK.
Environ Toxicol Pharmacol. 2015, 39(1), 259-70.

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth.
Ahn JH, Yang YI, Lee KT, Choi JH.
J Cancer Res Clin Oncol. 2015, 141(2), 255-268.

Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition.
Kim RK, Suh Y, Yoo KC, Cui YH, Hwang E, Kim HJ, Kang JS, Kim MJ, Lee YY, Lee SJ.
Cancer Sci. 2015, 106(1), 94-101.

Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis. Arch Pharm Res.
Choi JS, Haulader S, Karki S, Jung HJ, Kim HR, Jung HA.
Arch Pharm Res. 2015, 38(8), 1477-1487.